Promethazine and codeine really should be used in the course of pregnancy provided that the likely reward justifies the potential risk to your fetus.
Consider this medication by mouth with or with no food items as directed by your health practitioner, normally every four to six hrs as desired. This medication may be taken with food items if stomach upset takes place. Consume loads of fluids whenever you use this medication unless or else directed by your physician.
Unresponsive Cough The dosage of Promethazine HCl and Codeine Phosphate Oral Alternative shouldn't be increased if cough fails to reply; an unresponsive cough must be reevaluated in 5 times or quicker for achievable underlying pathology, like international human body or reduced respiratory tract ailment [see Dosage and Administration (two.3)].
Take the medication to your medication take-back again plan. Check with the pharmacy or regulation enforcement to find a locale.
Promethazine hydrochloride and codeine phosphate must be supplied to a Expecting lady provided that Plainly essential.
In people getting MAO inhibitors, an initial compact check dose is recommended to permit observation of any too much narcotic outcomes or MAOI conversation.
The subsequent serious adverse reactions are explained, or explained in increased depth, in other sections:
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Hemodialysis just isn't routinely made use of to improve the elimination of codeine or promethazine from the human body.
Codeine Carcinogenicity research have been performed with codeine. Two-calendar year experiments in F344/N rats and B6C3F1 mice were being carried out to assess the carcinogenic probable of codeine. No evidence of tumorigenicity was observed in male and female rats at codeine dietary doses approximately 70 and eighty mg/kg/working day (around akin to 15 and twenty situations, the MRHD with a mg/m2 basis, respectively).
When you are incredibly sleepy or have trouble waking up right after making use of this medication, end having this medication and talk with your doctor or pharmacist straight away. Your dosage may perhaps must be decreased.
Respiration issues (respiratory despair)that may lead to death and opioid withdrawal can come about if you start using or quit using other medicines whilst using Promethazine Hydrochloride and Codeine Phosphate Oral Alternative, together with:
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The opioid antagonists, naloxone and nalmefene, are unique antidotes for respiratory melancholy resulting from opioid overdose. For clinically substantial respiratory or circulatory depression secondary to codeine overdose, administer an opioid antagonist. An antagonist should not be administered while in the absence of clinically considerable respiratory despair. Since the period of opioid reversal is expected to get below the duration of action of codeine in Promethazine HCl and Codeine Phosphate Oral Option, meticulously keep track of the client until eventually spontaneous respiration is reliably reestablished.